Replies to post #17366 on NorthWest Biotherapeutics Inc (NWBO)

[Pyrrhonian]

Great stuff, thanks.

[investor_2013]

Thanks a lot for your time. Appreciate your post. Good to know we have new interim analyses at 148 and 198 events. I believe we could have ealy stop at these new interim analyses, based on the newly announced 55 paitent data.

[flipper44]

Ah yes, here it is. I'd been reading some old posts during the "administrative warning." :-) Anyway, I finally ran across something I recalled on several occasions but could not place. See re: link above from betweenthelines.

Enrollment estimates and trial length are based somewhat on the European sites all becoming active. They are higher volume hospitals (on average) and enroll at much faster rates than most of the US sites. Hoping for new trial sites soon. -- betweenthelines discussing his conversation with Dr. Bosch in August of 2014. -- post# 17366

I'm certain most people are yawning right now, but as Senti has been pointing out, the likelihood that we completed enrollment or have come very near to completing enrollment hinges on the fact that enrollment kept accelerating towards the end of the trial. The German sites were mostly added at the 1st part of this year. I think most of you understand what it means if we stopped new screening in early August 2015 but kept enrolling into late October 2015. That is, if the European hospitals are "higher volume hospitals" that "enroll much faster," then it is likely we went from 300 enrolled to somewhere near 348 by early November.

Just thinking out loud.

(P.S. Thanks for your efforts as moderator Tzor!)