Replies to post #11499 on NorthWest Biotherapeutics Inc (NWBO)

[sentiment_stocks]

Thanks for all your work Evaluate - I'm going to read through this a little later but I'm sure many unable to hear the call today will appreciate the time you put into this. :)

[flipper44]

Thanks Evaluate. Very Accurate, imho.

[gnawkz]

Evaluate, thanks a bundle for the work summarizing all the points from the conference call.

[staccani]

Thank you Evaluate, very useful and helpful. I am not a doctor, but it appears that even in the cases where a progression of the disease /increase in the size of the tumor was seen, that was in fact due to increasing area of necrosis. Does it mean that DCVax Direct may prove effective later on on these tumors as well?

[iclight]

Thanks for that. I was sitting on a train home itching to hear it but couldn't get a good cell signal to sign in.

[BioInfo]

Evaluate, thank you for providing CC report. You did a great job, it almost felt as if I was reading a PR.

[koman]

Nice summary of the conference call. I tried listening but it stopped in the middle for whatever reason. Did she ever state whether future trials will include combo trials with immune checkpoint inhibitors. That seems the most logical choice. I have no idea why choosing multiple tumor injections make any sense at all as the next step. shouldn't one tumor site be enough to illicit an immune response against the rest? Also, in terms of safety, it was good to note that there is some fever which is a good indication that the immune system is working. Yet, when I read about the CART technology against blood cancer, the fever is ridiculously high and dangerous for the patient but a lot of them are getting "cured" which shows that the immune system is really cooking the targeted cancer cells. It would be nice to see the same reaction in solid tumors because fevers and other symptoms of an overactive immune system can be managed. Also, those who want to complain about AF you are wasting your time. It's been done (I have done it in the past) and he only gets a warning from the SEC if at all and AF will be submissive for a little while but he gets back to what he is good at. Plus, his criticism is valid. I don't see how further injections of DC to boost the immune reaction will help at all if the reason why it isn't working as well as we hope is because of the immune checkpoint inhibition. Boost all you want but it doesn't address the main issue which is immune suppression. I doubt any pI/II data will hold up in a double blind pIII with Direct. JMHO