Conclusions This advisory was undertaken to summarize the current evidence on the consumption of omega-6 PUFAs, partic- ularly LA, and CHD risk. Aggregate data from randomized trials, case-control and cohort studies, and long-term animal feeding experiments indicate that the consumption of at least 5% to 10% of energy from omega-6 PUFAs reduces the risk of CHD relative to lower intakes. The data also suggest that higher intakes appear to be safe and may be even more beneficial (as part of a low–saturated-fat, low-cholesterol diet). In summary, the AHA supports an omega-6 PUFA intake of at least 5% to 10% of energy in the context of other AHA lifestyle and dietary recommen- dations. To reduce omega-6 PUFA intakes from their current levels would be more likely to increase than to decrease risk for CHD.