NorthWest Biotherapeutics Inc (NWBO)

[longusa]

RR, from reading the NIH and Linda Liau research docs, DCVax (and other immunotherapies) is more effective if the cancer cells are in the process of dying as the antigens are more readily available for uptake. That is what I gleaned from those docs anyway. I used to think that an immunotherapy would have better effect if it could be the SoC alone, but not the case. So I don't think it makes sense to replace SoC - there needs to be some prior treatment to start the cancer cell death.

My take on the multiple injections is that cancers are able to mask themselves from the immune system. That is what the PD1 / PD-L1 inhibitors are aimed at as the PD1 pathway is a normal mechanism for the immune system not to attack healthy tissue that gets also used by cancers (so I expect these PD1 inhibitors will probably have some nasty side effects). So the multiple injections (I think) are needed to keep the immune response against the cancer going over time.