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Re: foxhound02 post# 5527

Friday, 03/07/2014 10:22:52 PM

Friday, March 07, 2014 10:22:52 PM

Post# of 709082
I think your interpretation is a fair reading.

RE: The alternative group….you almost need to look at the pseudo-progression trial as another trial that does not direct the primary trial, but instead must not be forgotten. These aren't sneak peaks against the rules for sequential analysis; instead one trial has possibly reached its primary endpoint, but the second trial must not be destroyed by prematurely unblinding the first. The "second trial," so to speak, must be handled just as carefully as the first, but investors have no idea that is the case. Ultimately, they also must be evaluated as one unit.

Maybe that makes more sense.

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