Amarin Corp Plc (AMRN)

[Ajax133]

PCSK9:. There have been infrequent reports of (reversible) neurocognitive changes with all statins and language to that effect is included in their labels. Results of studies to specifically investigate these neurocognitive changes (ie studies with neurocognition as their primary endpoint) have been not determined a clear relationship. Comments made by FDA officials reflect these findings. As for potential mechanisms for effects on the brain, proposed mechanisms relate statins' inhibition of cholesterol synthesis. However, that mechanisms have been proposed does not signify that a link necessarily exists in our opinion.