NorthWest Biotherapeutics Inc (NWBO)

[flipper44]

Doc Logic.

Larry Smith reprinted Doc Logic's statement on January 28, 2014. It's so enlightening, I thought I would also reprint it.

Doc logic said that investors must understand the need for a more complete antigen presentation (as is the case with DCVax-L) to the dendritic cells is only one part of what DCVax-L does. Another important aspect of the product is that it takes signaling compounds to the proper sites so that helper T-cells and killer T-cells can be properly informed and activated and T-regulator cells can be inactivated so that the proper immune response can occur.

DCVax-Direct has more than 10x the amount of signaling compounds on each dendritic cell than those of DCVax-L. These compounds in the tumor microenvironment are immediately put to work and because the tumor has been damaged already, as per trial protocol, the ability of the dendritic cell to identify antigens is improved and mobility is not more fully impaired as would be the case with a healthy tumor environment.

An article from Neuro Oncol magazine dated April12, 2010 titled “Intratumoral dendritic cells increase efficacy of peripheral vaccination by modulation of glioma microenvironment” which essentially states that intradermal (i.e. DCVax-L) vaccination is improved by intratumoral (ie. DCVax-Direct) vaccination because the microenvironment of the tumor is changed by doing so. This evidence is only a small part of the evidence that I have found that supports a long term investment in NWBO.

-- Larry Smith quoting Doc Logic