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Re: BioInfo post# 4000

Tuesday, 02/04/2014 5:34:29 PM

Tuesday, February 04, 2014 5:34:29 PM

Post# of 700559
I'm not certain Merck's trial was very similar to NWBO's DCVAX trials.

Methods. Subjects with metastatic melanoma were vaccinated with mature DCs transfected with RNAs encoding melanoma antigens MART1, MAGE-3, gp100, and tyrosinase. These DCs were derived from monocytes that were untransfected (Arm A; n = 4), transfected with control siRNA (Arm B; n = 3), or transfected with siRNAs targeting the 3 inducible iP subunits (Arm C; n = 5).


--J Clin Invest. 2013 July 1; 123(7): 3135–3145.
Published online 2013 June 24. doi: 10.1172/JCI67544

[Emphasis added]

However, what I would say is that their use of dendritic cells in this study plus the pretrial clinical experiment liken back to where NWBO was in 2002 with their DCVAX technology.
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