![](https://investorshub.advfn.com/uicon/430424.png?cb=1554906782)
Sunday, January 19, 2014 11:09:10 AM
Nice review with many detailed resection studies. The difference between the DCVAX-L study and those studies is this:
1. DCVAX-L Study: "Patients must not have progressive disease at completion of radiation therapy. Patients with suspected pseudo-progression will be enrolled and analyzed separately." Clinical trials.gov.
In other words, while I believe your numbers regarding PFS for control groups are very reasonable if patients were filtered immediately after surgery, I contend that since the baseline selection occurs after chemo/radiation (Stupp's protocol), the PFS in the control group will be higher than one might otherwise expect. Likewise, because the selection is conducted post-chemo radiation, and due to the synergistic effect of DCVAX-L in such cases, the PFS in the experimental group will be much longer. Remember, this study originated in 2005. The reason it was paused -- in addition to economic circumstances -- was to develop an appropriate placebo (much more difficult than one would think). Prior to pausing the study, if not placed in the experimental arm, the non treatment group did not want to continue in the study. Consequently, I believe the 33 carryovers were very likely to be in the experimental arm. That said, their data points for this trial give us a time scale that is rarely achievable in such trials. I contend when the trial started up enrollment again, they had to catch-up the control group enrollment. I think you can take it from there what this implies regarding where the more recent events mostly materialized from.
2.As far as visualizations, I'll leave that homely analogy alone. I will run/play with your numbers, however, it will take me a bit more time than you. I think the key point in my visualization left wanting was the fact that the control group still will curve to a finite endpoint length of survival, where only 2-5% will extend survival beyond 5 years.
In the meantime, today I am obligated to challenge several different curves with crystallized H2O, so I may be a bit slow getting back to you.
Recent NWBO News
- Biophma Announces Exclusive In License for Dendritic Cell Technology, Sending Shares Higher • AllPennyStocks.com • 06/17/2024 04:40:00 PM
- Form 8-K - Current report • Edgar (US Regulatory) • 06/04/2024 09:11:16 PM
- Form DEF 14A - Other definitive proxy statements • Edgar (US Regulatory) • 06/03/2024 09:22:55 PM
- Form PRE 14A - Other preliminary proxy statements • Edgar (US Regulatory) • 05/22/2024 08:13:36 PM
- Form 10-Q - Quarterly report [Sections 13 or 15(d)] • Edgar (US Regulatory) • 05/10/2024 09:04:57 PM
- Form NT 10-K - Notification of inability to timely file Form 10-K 405, 10-K, 10-KSB 405, 10-KSB, 10-KT, or 10-KT405 • Edgar (US Regulatory) • 03/01/2024 10:04:38 PM
- Form 4 - Statement of changes in beneficial ownership of securities • Edgar (US Regulatory) • 12/02/2023 01:31:35 AM
- Form 8-K - Current report • Edgar (US Regulatory) • 11/16/2023 10:11:54 PM
- Epazz, Inc. (OTC Pink: EPAZ) ZenaDrone Demonstration to Defense Departments of UAE and Saudi Arabia • InvestorsHub NewsWire • 11/15/2023 12:19:31 PM
- Form 10-Q - Quarterly report [Sections 13 or 15(d)] • Edgar (US Regulatory) • 11/09/2023 09:30:39 PM
- Epazz, Inc. (OTC Pink: EPAZ) US Navy Collaboration ZenaDrone 1000 • InvestorsHub NewsWire • 11/09/2023 01:00:34 PM
- Epazz, Inc. (OTC Pink: EPAZ) US Navy Collaboration ZenaDrone 1000 Extreme Weather Demo • InvestorsHub NewsWire • 11/07/2023 12:29:43 PM
- Form 10-Q - Quarterly report [Sections 13 or 15(d)] • Edgar (US Regulatory) • 08/09/2023 08:36:14 PM
Last Shot Hydration Drink Announced as Official Sponsor of Red River Athletic Conference • EQLB • Jun 20, 2024 2:38 PM
ATWEC Announces Major Acquisition and Lays Out Strategic Growth Plans • ATWT • Jun 20, 2024 7:09 AM
North Bay Resources Announces Composite Assays of 0.53 and 0.44 Troy Ounces per Ton Gold in Trenches B + C at Fran Gold, British Columbia • NBRI • Jun 18, 2024 9:18 AM
VAYK Assembling New Management Team for $64 Billion Domestic Market • VAYK • Jun 18, 2024 9:00 AM
Fifty 1 Labs, Inc Announces Acquisition of Drago Knives, LLC • CAFI • Jun 18, 2024 8:45 AM
Hydromer Announces Attainment of ISO 13485 Certification • HYDI • Jun 17, 2024 9:22 AM