NorthWest Biotherapeutics Inc (NWBO)

[flipper44]

Article to Understand Dendritic Cell Immunotherapy. (Best Yet).


It indirectly shoots down my (last post) theory that Dendritic Cell expression to naive t-cells can also happen on the tumor, but does not preclude other dendritic cell localized tumor expression/exchanges (see innate immune system cells). It also explains why a dendritic cell stimulated at the tumor site is different than a dendritic cell stimulated at the lymph node location.
These ideas might explain the nonresponse PFS with intranodal injections, but significant (but not equivalent to L or Direct) OS response with intranodal injections.

I can't explain here in any sort of detail why this article also makes me confident about DCVAX, but maybe you will draw your own insights and ahas. To me, NWBO is even ahead of the foundational knowledge laid out in this article.

http://www.nature.com/nrc/journal/v12/n4/full/nrc3258.html