NorthWest Biotherapeutics Inc (NWBO)

[john1045]

Found this very interesting in reply to Josh Ginsburgs article on NWBO pose Onyx Like Potential! Notice in bottom of first link (JH7CDU) at #4 include Dr. Liau!


http://1.usa.gov/JH7CDU

http://1.usa.gov/JH7CU8

"An immune response measured by ELISPOT assay performed after the fourth vaccination was detected in 5 of the 8 (63%) patients.30 Preliminary data presented from a randomized phase 2 study suggested that patients with high-grade glioma receiving DC-based immunotherapy after radiation and chemotherapy had an improved survival compared with the control group who only received conventional treatment.31 This data combined with our current observations suggest that the immune suppressive effect associated with prior RT and chemotherapy does not prevent and, on the contrary, may predispose to, successful immune stimulation by a DC vaccine.

http://bit.ly/JH7CUc

Presenting the trial results, Dr. Yang said, "In the glioblastoma grade 4 group...overall survival in the whole tumor–pulsed lysate group is significantly improved compared to the [DCs] pulsed with peptide, and this difference was statistically significant, with a P value of .0357." Earlier results on 26 of the patients showed an overall survival of 35.5 months vs 17.5 months in favor of the whole-tumor lysate vaccine group.

"In summary, this suggests that...whole-tumor lysate-pulsed [DC] therapy is associated with improved overall survival compared...with specific peptide-pulsed [DC] therapy, and that the time to progression was not significantly different in these 2 groups," Dr. Yang told the audience.

He also monitored peripheral blood immune cells in the patients and found that the patients who received the whole-tumor lysate DC vaccine and who had the longest survival had decreased CD4+/CD25+ regulatory T cells (P = .029), which are immunosuppressors. Conversely, in the peptide-pulsed DC group, the investigators saw no change in the regulatory T cells. "This may potentially suggest a mechanism for this difference in overall survival," Dr. Yang said.