Amarin Corp Plc (AMRN)

[Biobillionair]

Grant
That's the main mechanism of action.

"Eicosanoids are derived from either omega-3 (?-3) or omega-6 (?-6) fatty acids. The ?-6 eicosanoids are generally pro-inflammatory; ?-3s are much less so. The amounts and balance of these fats in a person's diet will affect the body's eicosanoid-controlled functions, with effects on cardiovascular disease, triglycerides, blood pressure, and arthritis. Anti-inflammatory drugs such as aspirin and other NSAIDs act by downregulating eicosanoid synthesis."

EPA is the building block for the anti-Inflamatory eciosanoids. Omega 6's the Inflamatory eciosanoids.

"The biological effects of the omega-6 fatty acids are largely mediated by their conversion to omega-6 eicosanoids that bind to diverse receptors found in every tissue of the body. The conversion of tissue arachidonic acid (20:4n-6) to omega-6 prostaglandin and omega-6 leukotriene hormones provides many targets for pharmaceutical drug development and treatment to diminish excessive omega-6 actions in atherosclerosis,[2] asthma, arthritis, vascular disease, thrombosis, immune-inflammatory processes, and tumor proliferation. Competitive interactions with the omega-3 fatty acids affect the relative storage, mobilization, conversion and action of the omega-3 and omega-6 eicosanoid precursors (see Essential fatty acid interactions)."

Vascepa is important because it can increase EPA blood levels 30 times higher than a gram for gram OTC fish oil. This is why it works, and fish oil just gives you the fish burps. It's impossible to get the same EPA blood levels with OTC.. you'd shit yourself.

DHA lowers trigs better than EPA but has proven to also raise LDL ( bad cholesterol) this is historically connected to poor CV outcomes.

Your body doesn't need the extra DHA, it regulates the amount needed and can easily produce it from EPA. The reverse is not true, your body doesn't normally convert DHA to EPA .