Rivulet Media Inc (fka RIVU)

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BMSN .0032 POISED TO BUST INTO THE $TRILLION PHARMA SCENE ANY DAY NOW!

Regen Biopharma, Subsidiary of Bio-Matrix Scientific Group is that much closer to the US FDA's Orphan Drug approval to begin clinical trials for their Trademark autologous (patient derives) stem cell treatment HemaXellerate for Aplastic Anemia.

HemaXellerate is just one of several proposed treatments from the patented HemXellerate approach to combating life threatening diseases.

And if teaching a patient's body to attack deadly intruders by way of their own stem cells is not out-of-this-world, try this on for size:

siRNA GENE SILENCING: In a nutshell, Dr. Wei-Ping Min, long-time friend of & mentor to Dr. Thomas Ichim, CSO of Regen Biopharma, has developed a process whereby the genetic components contributing to the growth of cancer are silenced.

But, they are not stopping there--the latest licensing deal with Benitec Australia coupled with Dr. Min's siRNA science not only will tell cancer to shut up and get the bleep out, but will also help to give a mega boost to the patients immune system.

Oh, and the patented treatments have world-wide protection.

CAN YOU SAY CHA-CHING?

BIG PHARMA AND THEIR DEEP POCKETS ARE WATCHING!

Bio-Matrix Scientific Group:

-----Fully Reporting
-----Totally Transparent
-----Comprised of world renowned scientists considered leaders in the world of stem cell medicine & gene silencing
-----Aggressively pursuing their position in a trillion dollar pharmaceutical market while at the same time working just as hard to improve quality of life!
-----NO DUMPING OF SHARES BY THE COMPANY CEO REGARDLESS OF WHAT SOME WILL HAVE YOU THINK!

BMSN--a steal @ 0032. A price that is soon to be but a very distant memory!


SAN DIEGO, CA--(Marketwired - Aug 16, 2013) - Bio-Matrix Scientific Group Inc. (OTCQB: BMSN) provided an update today on the cancer immunotherapy program currently under development by Regen BioPharma Inc., a wholly owned subsidiary of BMSN.

"The operating objective of Regen BioPharma is to identify, develop, and commercialize intellectual property which has demonstrated preclinical efficacy, and addresses significant markets," said David Koos, CEO of Regen BioPharma.

"On May 6, 2013, we acquired issued patent # 8,389,708 from Dr. Wei-Ping Min of the University of Western Ontario, as well as proprietary know-how covering means of inducing immune mediated killing of melanoma and breast cancer. This data has been published in two peer-reviewed scientific publications (1, 2). Last week, we licensed from Benitec Australia Ltd rights to patented biological mechanisms that control the gene manipulation processes. These processes dovetail into the Wei-Ping Min technology to induce regression of cancer. We believe that the combination of these patents provide us international patent coverage for development of this technology into clinical trials and eventually as a non-toxic alternative to current day chemotherapy and radiotherapy."

Current day cancer immunotherapy is based on stimulating immune responses to cancer cells. Unfortunately, in the majority of patients, the tumor reduces ability of the immune response to kill the tumor resulting in reduced efficiency of many prior cancer vaccines.

By blocking the mechanisms by which the tumor escapes from the immune response, several companies have developed successful cancer drugs, for example, Bristol-Myers Squibb, which developed Ipilimumab which had 2012 sales of $706 million (3). Ipilimumab blocks the immune inhibitory molecule CTLA-4, which results in augmentation of immune responses.

"Regen's approach, which is currently in late-stage preclinical testing, involves blocking the immune suppressive gene IDO, while concurrently using dendritic cells to stimulate the immune system," said Dr. Thomas Ichim, Chief Scientific Officer for Regen BioPharma. "Through the combination approach, and based on the published data, we are hoping to offer a new weapon in the fight against breast cancer."

Regen BioPharma is currently conducting toxicology experiments on its therapeutic approach, with anticipated FDA filing in the 4th Quarter of 2013.

References
1. Zheng et al. Silencing IDO in dendritic cells: a novel approach to enhance cancer immunotherapy in a murine breast cancer model. Int J Cancer. 2013 Feb 15;132(4):967-77.
2. Zheng et al. Reinstalling antitumor immunity by inhibiting tumor-derived immunosuppressive molecule IDO through RNA interference. J Immunol. 2006 Oct 15;177(8):5639-46.
3. www.fiercepharma.com/special-reports/yervoy/top-20-orphan-drugs-2018

About Regen BioPharma: Regen BioPharma, Inc., a subsidiary of Bio-Matrix Scientific Group, Inc. (OTCQB: BMSN), is a biotechnology company focused on identifying undervalued regenerative medicine applications in the stem cell space and rapidly advancing these technologies through pre-clinical and Phase I/ II clinical trials. For more information refer to the company's website http://www.regenbiopharma.com/