Amarin Corp Plc (AMRN)

[Biobillionair]

The body naturally coverts EPA to DHA...it's a feed back mechanism closely regulated. If your body has no need for more DHA it won't convert EPA to DHA. Conversely if you have an excess of DHA your body has limited mechanism to use or covert it to a useful product. As JL stated, EPA is closely related to AA and the excess produces the good ecosinoids.

"EFFECTS OF EPA SUPPLEMENTATION ON PLASMA FATTY ACIDS

Supplementation of adults with ˜4 g/d of pure EPA ethyl ester results in significant increases in EPA concentrations in whole plasma and plasma or serum phospholipids, but no increase in DHA concentrations, which is consistent with the poor enzymatic conversion of EPA to DHA (64, 68, 72, 73). A meta-regression dose-response analysis of pure EPA supplementation could not be performed because a sufficient number of studies across a range of EPA doses were not available."

http://ajcn.nutrition.org/content/83/6/S1467.full

-----------

There very well may be a carcinogenic level of chronic DHA, but you won't achieve it with taking pure EPA...

The FDA should look into this when the consider Lovaza like Epnova's very VERY high DHA levels.

Will