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Saturday, June 22, 2013 3:59:03 PM
Peregrine has clearly shown that bavituximab plus a chemotherapy can offer patients greatly enhanced survival in very serious and life-threatening cancers. We have just seen it in the recent phase II second-line NSCLC trial. The trial has just shown the oncology community an amazing survival result of 11.7 months MOS. Bavi outperformed all historical treatments of this disease.
That greatly increased survival is wonderful for patients and their families, but there something even more amazing about bavi and anti-PS. After treatment considerable percentages show, Complete Responses: Tumors completely gone. This can also be referred to as remission. Scientists working with anti-PS have called it “cure”.They have found that when, after successful treatment of tumors with anti-PS, and there is a re-challenge with tumor material, subjects will reject the tumor because they have developed immunity to the cancer.
First let’s look at a generic K-M plot:
![](http://investorshub.advfn.com/uimage/uploads/2013/6/22/dczrgkaplan-meier_remission_chart_.jpg)
Now look at this pre-clinical trial K-M plot of anti-PS treatment of cancer:
![](http://investorshub.advfn.com/uimage/uploads/2013/6/22/oxbycAnti-PS_and_Irradiation_Pre-Clinical_2009.jpg)
http://clincancerres.aacrjournals.org/content/early/2009/11/02/1078-0432.CCR-09-1499.full.pdf
Finally let’s look at Peregrine’s recently published K-M plot of their phase II second-line NSCLC trial:
![](http://investorshub.advfn.com/uimage/uploads/2013/6/22/tutqlSecond_Line_NSCLC_ASCO_13_K_M_Plot.jpg)
Note that in the phase II second-line NSCLC K-M plot, approximately 30% of the bavi treatment arm patients are surviving out in extended time toward 30 months. These were last chance lung cancer patients: EXTRAORDINARY!
In all three K-M plots above we see the tell-tale tail that extends out in time to show extraordinary survival well beyond the MOS. These extended tails on the K-M plots can indicate: remission, complete responses (CR), and acquired immunity to cancers.
BAVI WORKS, AND WORKS SAFELY! AND, BAVI IS PROVING TO BE A POWERFUL LEADING EDGE IMMUNOTHERAPEUTIC ANTIBODY.
IMO
sunstar
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