Amarin Corp Plc (AMRN)

[Biobillionair]

JL, The chemerin receptor is the target of RvE1. Check this out:


http://www.iuphar-db.org/DATABASE/LigandDisplayForward?tab=biology&ligandId=3333

EPA is step 1 in the production of RvE.

EPA -->(ASA/COX2)-->18-R-hydro(per)oxy-EPA -->(5-LOX)-->5 S-hydroperoxy, 18R-hydroxy-EPA-->(reduction rxn)--> RvE2......different branched rxn from 5S-hydroperoxy, 18R-hydroxy-EPA-->5,6-epoxy, 18 R-hydroy-EPA--> (LTA4H)--> RvE1

Think of the ASA as a catalyst...Maybe?

All the molecules following EPA in the above reaction are small variations of the EPA molecule and would be considered active metabolites of EPA, I suggest Amarin Patent these using their original EPA patent.

The reason Amarin has a lock on the metabolites: obviously any layman could figure out the metabolites are active and considered prior art as they are posted here on an IHUB Amarin investor website. (Someone save that for legal;)

Williams