Amarin Corp Plc (AMRN)

[Biobillionair]

JL,
Haven't read through all your posts...did you cover this? Because the combo of ASA and EPA is essentially a Resolvin drug, exerting inhibitory action on leukocyte transendothelial migration and IL-2 production. That's a BFD, right? Will

"Aspirin exerts its actions by the inhibition of both COX-1 and COX-2 (cyclooxygenase 1 and 2) which has a direct negative effect on prostaglandin synthesis. It irreversibly acetylates COX-2 which loses the ability to generate prostaglandin intermediates. However, COX-2 retains oxygenase activity which results in the production of several types of anti-inflammatory mediators. This pathway describes the aspirin triggered conversion of : 5Z8Z11Z14Z17Z-EICOSAPENTAENOATE to anti-inflammatory mediators of the resolvin E1 and 2.. About this Pathway Aspirin mediated acetylation of COX-2 triggers the synthesis of resolvins E1 and E2 from eicosapentaenoate. Resolvin E1 has been found to be 5S,12R,18R-trihydroxy-6Z,8E,10E,14Z,16E-eicosapentaenoate . The enzyme 5-lipooxygenase is pivotal in the catalysis of 18-HEPE to 5S,18-HEPE which leads to the downstream production of resolvins E1 and E2 . Resolvin E1 has proven inhibitory action on leukocyte transendothelial migration and IL-2 production."