Amarin Corp Plc (AMRN)

[jessellivermore]

"IMHO the future lies in combo pills"

While combo pills likely have a bright future, IMHO V's future is not going to be limited by its relationship to the statins..That is simply giving too much respect to the statins. My view is CVDs comprise a very large, but by no means complete fraction of Vascepa's wide panorama of therapeutic indications.

Within the CVD indication, even though statins are the giants now, they will eventually assume a secondary role behind drugs which primarily address inflammation, the core problem in CVD..While it is true statins also reduce inflammation, seemly this is a result of there ability to reduce the LDL-P (LDL particle numbers) which is the best known risk predictor..Truth is statins are better at lowering cholesterol because they operate in the liver to decrease cholesterol synthesis..a very indirect approach and one not without side effects..

EPA acts to reduce chronic inflammation at a more basic (dietary and cellular level) level...The best evidence for the effectiveness of this approach is the large population studies that show if you improve the EPA/AA ratio, you cut the incidence of CVDs...Statins are bandaids, EPA prevents the cuts..

So my vision is not a happy world where EPA and statins get married and live happily ever after. I see EPA (Vascepa) relieving us of the burden of these unpleasant and expensive drugs...

":>) JL