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Hot On The TRAIL Of Graft Vs. Host Disease

Main Category: Lymphoma / Leukemia / Myeloma
Also Included In: Stem Cell Research
Article Date: 17 May 2013 - 1:00 PDT

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Hot On The TRAIL Of Graft Vs. Host Disease

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For patients with leukemia and other hematological malignancies, transplantation of hematopoietic stem cells (HSCT) can be a powerfully effective therapy. In addition to the desirable anti-tumor effect, transplanted cells can also attack the host tissue, resulting in graft-versus-host disease (GVHD).

In this issue of the Journal of Clinical Investigation, Arnab Ghosh and colleagues at Memorial Sloan-Kettering Cancer Center found that expression of a protein that causes cell death, TRAIL, in transplanted cells was critical for an effective anti-tumor response. Immune cells engineered to express higher levels of TRAIL killed the cells that cause GVHD and increased anti-tumor activity. In an accompanying commentary, Nelson Chao suggests that new therapeutics may take advantage of TRAIL-expressing cells to promote an anti-tumor response without putting patients at risk for GVHD.

TITLE: Fratricidal TRAIL+T cells suppress GVHD and augment anti-tumor activity after bone marrow transplantation
View this article at: http://www.jci.org/articles/view/66301?key=66e50de3cd0d7e99a4d8

ACCOMPANYING COMMENTARY TITLE: Blazing a new TRAIL in hematopoietic cell transplantation
View this article at: http://www.jci.org/articles/view/69909?key=43f0101604c8f6bb12da

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Article adapted by Medical News Today from original press release. Click 'references' tab above for source.
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