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Re: poorgradstudent post# 160717

Friday, 05/03/2013 12:34:20 PM

Friday, May 03, 2013 12:34:20 PM

Post# of 252557
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Looking at that paper, along with another of theirs*, the data for lack of c-MET expression seems pretty convincing to me. There is even a lack of transcript.



Thanks for looking. As I noted originally I agree that it is convincing that there is a lack of transcript for unmutated c-Met. But my question is whether looking for the c-Met unmutated mRNA will find heavily mutated c-Met (as many consitutively active c-Mets are). I.e. I believe that the two assays they did would miss a high fraction of constitutively actived c-Met. But that said, the reason I asked for vin (or you) to look is that I don't know the precise limits of the two assays they used - so I was looking for someone to comment on that.

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