Biotech Values

[poorgradstudent]

c-MET:

They claim Tiv was effective against the TOV112D cell line which "doesn't express c-Met". But the source paper for the claim that it doesn't express c-Met is far from conclusive since (in a quick look) they appear to have looked only for full, unaltered c-Met

Looking at that paper, along with another of theirs*, the data for lack of c-MET expression seems pretty convincing to me. There is even a lack of transcript.





*An uncleavable form of pro–scatter factor suppresses tumor growth and dissemination in mice
Massimiliano Mazzone, Cristina Basilico, Silvia Cavassa, Selma Pennacchietti, Mauro Risio, Luigi Naldini, Paolo M. Comoglio, Paolo Michieli
Published in Volume 114, Issue 10
J Clin Invest. 2004; 114(10):1418–1432 doi:10.1172/JCI22235