Three weeks on Vascepa...
To begin with...my Trigs are normal, slightly elevated LDL, on anti hypertensive med and aspirin, exercise 3-4 times a week, work over 40 hours a week, am 5'11 and a half, and weigh 175 pounds..No CVD history, eat healthy based on the Zone diet..and am a typical Type A..
Began Vascepa off label because my belief that chronic "silent" inflammation caused our American diet which is too high in Omega^ PUFAs, effecting the Arachidonic Acid/EPA ratio which sets the thermostat on our inflammatory and immune systems too high..Leading to a host of auto immune and degenerative diseases of which diabetes and atherosclerosis are two of the most important..My belief is based on thousands of hours of research into this complicated and frequently confusing field..
Vascepa caps are large, but seemingly ergonomically designed so taking even three at a time is not particularly difficult the capsule being very smooth.
Vascepa is taken two caps twice daily with meals..As a typically non compliant male..I have had no trouble remembering to take the drug..I have missed doses on two days.
There is little or no GI distress...
For the first ten days I continued my morning aspirin as normally if I do not take it I feel sluggish..Ten days ago I stopped the aspirin going on the theory that aspirin is non specific blocker of COX receptors, blocking the expression of both good and bad eicosanoids...Since EPA and AA react on the same receptors, EPA expressing mainly "good" eicosanoids, and AA "bad"..The good being defined as those raising cyclic Amp levels, and the bad elevating pro inflammatory leukotienes, thromboxanes etc..The aspirin would inhibit the production of good eicosanoids which are essential to feel your best...Well that is pretty much what happened..Stopping the aspirin lead to a heightened sense of well being, less underlying anxiety, more energy, more clarity..This was definitely related to meal cycles, because after about 4 hours of not eating the effect wore off, but returned after a balance low glycemic index meal.
As reported before I also have had trouble with very dry eyes Right>>>Left..and was putting drops in the right almost hourly..This has greatly improved on EPA...no drops..
So anyway just starting and will up date in two more months..
":>) JL
