Amarin Corp Plc (AMRN)

[jessellivermore]

cardiovascular outcome studies did not bear this out.

zz1...You are right to be skeptical, because extracting conclusions from downstream observations is dangerous because the levels of complication are such that small unforeseeable events can side rail the most beautiful hypothesis. A classic example would be the the award of the Nobel Prize in medicine to Minot and Murphy for identifying Folic Acid deficiency as the cause of Pernicious Anemia (PA)..Later William Castle correctly proved that PA resulted from lack of VitB12...He never got a Nobel Prize..

The case for EPA looks very strong...Population studies with favorable EPA/Omega6 ratios show lower incidence of CVD and CAD events..The pathophysiology is very compelling..The EPA and Arachidonic Acid inflammatory cascades are well mapped and EPA decreases the inflammatory effects of Omega6s, by decreasing their conversion into AA, and by competing for infammatory cell receptors...

Studying the trajectory of Omega6s in our diet from 1940 shows the incidence of CVD follows the rise of Omega6s..

Both JELIS and JUPITOR were actually quite suggestive (convincing to me)...That decreasing inflammation would improve CVD outcomes..JELIS was a very stern test, because the population was so healthy...only 27 deaths from heart attacks in a population of 18,000, over a 5 year period...No chance to show statistical significance for death rates in that group...JUPITOR a statin (Crestor) outcomes test "cherry picked" for patients with high imflammatory markers...They were the first statin study to show benefits in cholesterol patients with no CAD history...

In medicine when everything lines up in the same direction you have the best chance of being right..The case for inflammation is very strong..The biggest problem now is shifting physicians away from treating lipids and toward treating infammmation..

":>) JL