Avid Bioservices Inc (CDMO)

[freethemice]

There are at least two things wrong with your "theory". Perhaps you remember this picture I once posted.
It shows how an antibody (in the picture the Ab is bound to a molecule) and the receptor may be internalized.
This is called receptor-mediated endocytosis. The receptor may be recycled and be returned to the cell surface,
but the ligand is destroyed inside the cell in a lysosome which has a very acidic environment. The picture is
somewhat simplified here.

So the antibody will not be sticking to the PS on the inside of the plasma membrane.
http://en.wikipedia.org/wiki/Endocytosis
The other big problem is that you seem to conveniently forget that bavituximab does not bind to PS.
It binds to the serum protein beta2-glycoprotein I. That is a protein which circulates in the blood stream,
it isn't present in the cell for bavituximab to bind to.
http://en.wikipedia.org/wiki/Beta-2_glycoprotein_I
Here is a reference you might want to look at. Molecular Cell Biology , by Lodish et al.
There is a section on receptor-mediated endocytosis.
You just can't make up ideas that are contrary to facts without some kind of evidence.
This is the last time I will post on this.