Avid Bioservices Inc (CDMO)

[entdoc]

FTM, this paper is enormous because it convincingly presents Bavi Imaging possibilities is an extremely favorable market position for clinicians, or the doctors ordering/supervising the actual injection/imaging/interpretation. The abstract you posted reminds us that phosphatidylserine (PS) is normally intracellular but becomes exposed on the luminal surface of vascular endothelial cells in tumors. What ARE vascular endothelial cells? VERY special body cells with very special properties, and found only as the inner lining of blood vessels. The Thorpe group optically imaged[take especial note of the term "optical imaged"] the flipped -PS markers on inner lining of cancer feeder-vessels with Peregrine's PGN635 MAB. NIR[important: NIR + near-infra-red] imaging was performed after injection of [dye-MAB] IRDye800CW-PGN635 into mice bearing glioma {Brain GBM?} or breast cancer. A clear tumor contrast[illuminated image] was visible 4 h later and became maximum 24 h later. Note! 24 hours later. The most fortuitous attribute of BavImage. The patient must come back to the doctor's office for a second time 24 hours later. That qualifies for medicare/insurance company criteria for enablling a second office visit charge. Voila! That helps enormously with radiologists/oncologists. Fluorescence microscopy confirmed that 800CW-PGN635 was binding to PS-positive tumor vascular endothelial cells. "BavImage worked well in vivo to provide sensitive tumor detection. Cost effective? I think so, even [especially] with a second visit required for "reading". What's the best part? That the imaging agent (Bavi) will also probably be therapeutic (!)...it can monitor its own antitumor activity...or is the best thing about BavImaging that the image is gathered with NIR, near infrared spectoscopy which, according to Koji, et. al., "has an advantage of being a portable and inexpensive device for functional ...imaging comparable to electroencephalography (EEG), as opposed to fMRI, positron emission tomography (PET) and magnetoencephalography (MEG). It doesn’t require severely limiting subject motion.... It can measure ... hemodynamic signals with a temporal resolution of 100 Hz or higher, significantly greater than fMRI or PET aiding in the resolution of the onset time of brain activation and in filtering physiological interference from the brain activation signals of interest. Measurements can bridge from the human level down to microscopic invasive measurements in animals enabling efficient translation of knowledge in both directions. Finally, NIRS is compatible with fMRI, PET, MEG, EEG enabling interference free simultaneous multi-modal studies of brain activation.
[ref]http://www.scholarpedia.org/article/Near_infrared_imaging