Avid Bioservices Inc (CDMO)

[freethemice]

New conference presentation on imaging.
SPIE BiOS, part of SPIE Photonics West, where the latest on biomedical optics, diagnostics and therapeutics, biophotonics molecular biology and genetics, optical microscopy, optical coherence tomography, and optogenetics research are presented and discussed.
2 - 7 February 2013
The Moscone Center
San Francisco, California

Imaging of tumor vascular endothelial cells in living mice
Paper 8596-3
Author(s): Dawen Zhao, Jason H. Stafford, Heling Zhou, Philip E. Thorpe, The Univ. of Texas Southwestern Medical Ctr. at Dallas (United States)
Abstract
Phosphatidylserine (PS) is normally intracellular but becomes exposed on the luminal surface of vascular endothelial cells in tumors. Here we optically imaged exposed PS on tumor vasculature in vivo using PGN635, a novel human monoclonal antibody that targets PS. NIR imaging was performed after injection of IRDye800CW-PGN635 into mice bearing glioma or breast cancer. A clear tumor contrast was visible 4 h later and became maximum 24 h later. Fluorescence microscopy confirmed that 800CW-PGN635 was binding to PS-positive tumor vascular endothelial cells. Our studies suggest that tumor vasculature can be successfully imaged in vivo to provide sensitive tumor detection.
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Looks like a presentation of their recent paper, but with more results in a breast cancer model too.
http://www.transonc.com/abstract.php?msid=234