I'm not oblivious to the base rates. Every single DMD trial for AD has failed to date. But none have shown this kind of success in trials. The technology has changed a lot in the past 5 yrs (since most of current ph 3s were started) and the ability to select the right patients and ability to measure change and regulatory mindset on endpoints has vastly improved.
I also think this is a positive for gantenerumab, which is in a much better designed trial
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