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Re: mrwrn2010 post# 18570

Tuesday, 06/12/2012 10:14:41 AM

Tuesday, June 12, 2012 10:14:41 AM

Post# of 402540
In a Bloomberg article from 2008, Catherine Larkin describes the technology underlying 4 leading contenders to be the "abuse-resistant" opioid of choice.

(http://www.bloomberg.com/apps/news?pid=newsarchive&sid=aRZ.1B919WGE)

She cited:

1.) an unnamed Purdue product that had yet to be released...I'm guessing that that was OxyNeo. From "druggie blogs," it appears that OxyNeo is failing as a tamper-resistant alternative.

2.) Embeda (same basic strategy as ELTP's ELI-216) was voluntarily recalled.

3.) Remoxy has twice been turned down by FDA panels (http://www.medpagetoday.com/PainManagement/PainManagement/27252)

4.) ELI-216: the last man standing of these four (technology patented by Elite Pharmaceuticals; awaiting Phase III trials)

Note that other candidates have arisen: http://blog.pharmexec.com/2012/02/23/combating-opioid-abuse-with-science/

ENDO's Opana is not being well received from what I have read. It doesn't alleviate pain that well and druggies seem to love it: Here's a post by "tbone":

"I will tell you I have snorted oxy and opana. Opana is way better. Theres not even a comparison. The weird thing is though, Opana ER does not help with pain or give you any kind of buzz when takin orally. but when snorted theres nothing that even comes close to the buzz opana gives. I would not suggest doing opana, because if you think the withdrawal from oxycontin is bad, opana withdrawal is 10 times worst. It feels Deadly."

http://www.topix.com/forum/drug/oxycontin/TM91K5UR0BAQT927U

Anyway, that's my understanding of the situation (I'm just a Ph.D. biologist not a pharmacologist).






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