Avid Bioservices Inc (CDMO)

[entdoc]

CJ&FTM..while the west coast slept. Amazing stuff. Thanks foryour efforts. I've posted here several times that I can't understand why PPHM had not pushed forward with a fully human Cotara instead of the clunky chimeric MAB being used, and you found that PPHM has had it since at least 2000, and licensed it to MerckeAG. Mind-boggling. So the paper at AACR deals fusing anti-neoplastic IL-12 to a tumor-binding antibody, NHS-IL12, the fully humanized Cotara-like MAB developed by PPHM, an antibody which also targets necrotic portions of tumors because of its high affinity for single- and double-stranded DNA, which are often exposed as tumors outgrow their blood supply. "NHS-IL12 may therefore be useful against a wide range of solid tumors, and mouse models can be used to study its mechanisms of action." Love it. Thanks again.