I sure hope big pharma is involved cause if I'm Alex Gorsky, the new CEO over at J&J, who, until his recent promotion, ran their device division, I want to own a company which already has FDA approval on one of its devices which affects my Tylenol pain drug sales and has applications before the FDA for ActiPatch and ALLAY for Menstrual pain and cramping.
We also know an FDA advisory committee recommended limiting or stopping sales of drugs containing acetaminophen because of liver damage. Look at the data below on how many drugs contain it and the use for menstrual issues, which ALLAY deals with, chemical- free.
Just found this on Wikipedia....
"Acetaminophen causes three times as many cases of liver failure as all other drugs combined,[14] and is the most common cause of acute liver failure in the United States,[15][16] accounting for 39% of cases. While this generally occurs through overdosing,[6] the window of toxicity can increase at lower than toxic doses when acetaminophen is combined with alcohol, especially in heavier drinkers, or those with compromised liver function as a result of alcohol use.
Acetaminophen is metabolized in the liver, resulting in a by-product, N-acetyl-p-benzoquinone imine (NAPQI), that can damage liver cells, but is typically converted into a harmless substance by an antioxidant glutathione. However, large doses of acetaminophen overwhelms the body's supply of glutathione, resulting in destruction of the liver cells.[19]
People who have the highest risk for Acetaminophen related kidney failure include: heavy drinkers (three or more drinks per day), elderly men, and persons with pre-existing liver or kidney damage.[20]
A study published by the Journal of the American Medical Association in 2006 suggests problems even in healthy people taking the pain reliever as directed.[21] Healthy adults taking maximum doses of Tylenol for two weeks had abnormal liver test results. Dr. Neil Kaplowitz of the University of Southern California, co-author of the study, said, "I would urge the public not to exceed four grams a day. This is a drug that has a rather narrow safety window..."[22]
According to a preliminary study mixing acetaminophen and caffeine may cause liver damage, especially in heavy caffeine drinkers. Researchers discovered that caffeine can triple the amount of, N-acetyl-p-benzoquinone imine (NAPQI), the dangerous by product which destroys liver cells.[23] This reaction can also be caused by large doses of painkillers that combine caffeine and acetaminophen (e.g., Anacin, Excedrin & Midol). These products are often used to treat migraines and menstrual discomfort. Dr. Sid Nelson, a professor of medicinal chemistry at the University of Washington said, "Caffeine can interact with an enzyme that can form a toxic metabolite of acetaminophen in such a way that it increases the formation of that toxic metabolite".[24]
Symptoms from an overdose of acetaminophen typically appear after 24 hours, or in some cases up to 48 hours, however immediate treatment prior to the onset of symptoms can greatly improve the outcome. The antidote to acetaminophen overdose, N-acetylcysteine (NAC), is most effective when taken within eight-hours of an overdose.[25] Due to the delayed symptoms and the importance of immediate treatment, overdoses of acetaminophen kill about 12% of those who seek treatment.[17] Typical symptoms range from nausea and malaise to extreme upper abdominal pain in the region of the liver.
Tylenol is only one among many popular medications containing acetaminophen, but few users realize that it is contained in hundreds of other pain relievers and cold remedies, and that combined usage has a cumulative effect. Fifteen percent of accidental overdoses involve the simultaneous use of more than one product containing acetaminophen.[26] Products from common brands include acetaminophen: Excedrin, Midol, Theraflu, Alka-Seltzer and NyQuil, as well as prescription narcotics such as Vicodin and Percocet. Following the recommended dosages for each, but in combination can far exceed safe limits for acetaminophen intake.[27] The manufacturers of Tylenol recommend, "You should not take two or more products that contain acetaminophen at the same time."
Let's all hope big pharma is involved and looking closely at BIEL. What would a controlling interest in BIEL cost? Thanks very much for the thought provoking post doodles
AI
