ECYT this is probably old news, but havent seen it on the board. Seems like a solid entry point! European Medical Society http://www.ema.europa.eu/ema/index.jsp?curl=pages/medicines/human/orphans/2012/02/human_orphan_001023.jsp&mid=WC0b01ac058001d12b&murl=menus/medicines/medicines.jsp&jsenabled=true http://www.ema.europa.eu/ema/index.jsp?curl=pages/medicines/human/orphans/2012/02/human_orphan_001023.jsp&mid=WC0b01ac058001d12b&murl=menus/medicines/medicines.jsp&jsenabled=true http://www.ema.europa.eu/docs/en_GB/document_library/Orphan_designation/2012/02/WC500123294.pdf gl