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Summer2762

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Summer2762

Re: gfp927z post# 137740

Friday, 02/24/2012 3:17:44 AM

Friday, February 24, 2012 3:17:44 AM

Post# of 252275

The MTD for TH-302 is 575 mg/m2.



That's for monotherapy. With gemcitabine the MTD was established to be 340 mg/m2.

In general, be mindful of PFS data in an open label study (especially if the study allows crossover). I would wait to see a) LA/M ratio to validate 3.6m median for gem arm b) dropout ratios in both arms.
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