I see jq answered more clearly and succinctly then I could have. I was not as familiar with Relistor but since I can't get you or mcbio to do the work for me ...
In the Phase 2 NKTR-118 trial 3.6 for the 25mg arm vs. 1.9 for the placebo group. Now AZ is using a lower dose and different formulation for the Phase 3 trial. So even if one assumes slightly lower efficacy my prior contention is very much in tact namely that there is not a huge different (at least in efficacy) of these two therapies. Now if NKTR-118 is intended for regular use by those taking opioids (who are prone to constipation) I think that is a bigger opportunity then use to induce a bowl movement.
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