This funding is expected to enable ARIAD to continue treatment and follow-up of patients in the pivotal PACE trial of its investigational pan BCR-ABL inhibitor, ponatinib, in patients with chronic myeloid leukemia (CML) or Philadelphia-positive acute lymphoblastic leukemia (Ph+ALL) and, subject to further patient follow-up and data analysis in this trial, to file for marketing approval of ponatinib in the United States and Europe in the middle of 2012. ARIAD anticipates that this funding will also enable it to continue preparations for commercial launch of ponatinib in the United States and Europe and, if approved, to sell, market and distribute ponatinib in these and other markets on its own, allowing ARIAD to retain the substantial potential commercial value of ponatinib. ARIAD also expects that this funding will allow it to conduct additional clinical trials of ponatinib, including a Phase 3 clinical trial in newly diagnosed CML patients and clinical trials of ponatinib in Japan, as well as to complete the Phase 1/2 trial of AP26113, its investigational dual inhibitor of anaplastic lymphoma kinase and epidermal growth factor receptor, and, depending on the results of this trial, conduct a pivotal trial of AP26113 in patients with non-small cell lung cancer and to fund additional trials in the United States, Europe and Asia.
