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genisi

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genisi

Re: jellybean post# 132093

Wednesday, 11/30/2011 5:17:55 PM

Wednesday, November 30, 2011 5:17:55 PM

Post# of 252279

Given the amount of time 7977 has been in the clinic, no one has tried even a ex-Vivo experiment

Pharmasset looked at the drug-drug interactions with Telaprevir in vitro and concluded that antagonistic interaction is unlikely in clinical studies given the duplicity of enzymatic pathways available for delivery of the triphosphate intracellularly.

http://www.jbc.org/content/285/45/34337.full.pdf
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