Inhibition would be limited to drugs that rely on serine proteases for activation as that is the class of proteases that HCV protein falls into. And, yes, the fact that noone has tried this caught my attention. Really? Given the amount of time 7977 has been in the clinic, no one has tried even a ex-Vivo experiment. The VRUS data is clean, almost too clean, IMO, especially given the naked F sitting at C2 on the nucleoside.
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