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DonShimoda

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DonShimoda

Re: poorgradstudent post# 4480

Thursday, 12/30/2010 2:35:47 PM

Thursday, December 30, 2010 2:35:47 PM

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PGS, my intent wasn't to imply that a larger dose necessarily equates to a better drug only that the two drugs are different. To that end, my understanding is that unlike the other mTors, rida substitutes a phosphonate for the C40 hydroxyl which "may" allow it to bind FKBP12 at higher concentrations.
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