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poorgradstudent

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poorgradstudent

Re: DonShimoda post# 4477

Thursday, 12/30/2010 1:52:51 PM

Thursday, December 30, 2010 1:52:51 PM

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. Everolimus doses at 10mg, rida at 40mg "which results in very high exposure, very high and reliable inhibition of mTOR activity in pharmacodynamic studies, substantial blood levels and circulating levels of inhibitory mTOR activity."



The meaningful exposure depends on the affinity of the two drugs for FKBP12 / mTor. Therefore, total mass of drug given to patients provides little data without the accompanying affinity numbers.
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