CBA Florida Inc. (fka CBAI)

[dianebRN]

Time for an infomercial:
http://learn.genetics.utah.edu/content/tech/stemcells/sctoday/

I would encourage you to look at the full link as pictures are awesome. As a Pediatric Hematologist/Oncologist colleague explained to me stem cell therapy suffers from confusion related to the words stem cell as there are many types of stem cells in the process of the body making blood as well as umbilical cells, transplants etc. Regardless, what is considered useful for bone marrow transplant is also considered applicable to the other "products" used in transplant therapy. Often the expressions are used interchangeably because the utility is so closely related. So while you are technically correct that bone marrow transplants are not umbilical cell transplants they are indeed related and the article does have relevance.

STEM CELL THERAPIES TODAY

Did you know that several stem cell therapies are routinely used to treat disease today?

These include:

¦Adult Stem Cell Transplant: Bone Marrow Stem Cells
¦Adult Stem Cell Transplant: Peripheral Blood Stem Cells
¦Umbilical Cord Blood Stem Cell Transplant
Adult Stem Cell Transplant: Bone Marrow Stem Cells

Perhaps the best-known stem cell therapy to date is the bone marrow transplant, which is used to treat leukemia and other types of cancer, as well as various blood disorders.

Why is this a stem cell therapy?
Leukemia is a cancer of white blood cells, or leukocytes. Like other blood cells, leukocytes are made in the bone marrow through a process that begins with multipotent adult stem cells. Mature leukocytes are released into the bloodstream, where they work to fight off infections in our bodies.


Leukemia results when leukocytes begin to grow and function abnormally, becoming cancerous. These abnormal cells cannot fight off infection, and they interfere with the functions of other organs.

Successful treatment for leukemia depends on getting rid of all the abnormal leukocytes in the patient, allowing healthy ones to grow in their place. One way to do this is through chemotherapy, which uses potent drugs to target and kill the abnormal cells. When chemotherapy alone can't eliminate them all, physicians sometimes turn to bone marrow transplants.

In a bone marrow transplant, the patient's bone marrow stem cells are replaced with those from a healthy, matching donor. To do this, all of the patient's existing bone marrow and abnormal leukocytes are first killed using a combination of chemotherapy and radiation. Next, a sample of donor bone marrow containing healthy stem cells is introduced into the patient's bloodstream.

If the transplant is successful, the stem cells will migrate into the patient's bone marrow and begin producing new, healthy leukocytes to replace the abnormal cells.

Adult Stem Cell Transplant: Peripheral Blood Stem Cell Transplant



While most blood stem cells reside in the bone marrow, a small number are present in the bloodstream. These multipotent peripheral blood stem cells, or PBSCs, can be used just like bone marrow stem cells to treat leukemia, other cancers and various blood disorders. Since they can be obtained from drawn blood, PBSCs are easier to collect than bone marrow stem cells, which must be extracted from within bones. This makes PBSCs a less invasive treatment option than bone marrow stem cells. PBSCs are sparse in the bloodstream, however, so collecting enough to perform a transplant can pose a challenge.



Umbilical Cord Blood Stem Cell Transplant


Newborn infants no longer need their umbilical cords, so they have traditionally been discarded as a by-product of the birth process. In recent years, however, the multipotent-stem-cell-rich blood found in the umbilical cord has proven useful in treating the same types of health problems as those treated using bone marrow stem cells and PBSCs.

Umbilical cord blood stem cell transplants are less prone to rejection than either bone marrow or peripheral blood stem cells. This is probably because the cells have not yet developed the features that can be recognized and attacked by the recipient's immune system. Also, because umbilical cord blood lacks well-developed immune cells, there is less chance that the transplanted cells will attack the recipient's body, a problem called graft versus host disease.

Both the versatility and availability of umbilical cord blood stem cells makes them a potent resource for transplant therapies.