SCIENCE SPIN-OFFS

[chessmite]

worth browsing for ideas and leads for further DD

http://apl.aip.org/resource/1/applab/v97/i19


get ready to get excited

http://pubs.acs.org/doi/abs/10.1021/cm101314b?prevSearch=%2528ghassan%2Bjabbour%2529%2BNOT%2B%255Batype%253A%2Bad%255D%2BNOT%2B%255Batype%253A%2Bacs-toc%255D&searchHistoryKey=

Article
Efficient Light-Emitting Devices Based on Platinum-Complexes-Anchored Polyhedral Oligomeric Silsesquioxane Materials

* Abstract
* HTMLFull Text HTML
* PDFHi-Res PDF[1092 KB]
* PDFPDF w/ Links[859 KB]

* Figures

Xiaohui Yang†, Jesse. D. Froehlich‡, Hyun Sik Chae‡, Brett T. Harding‡, Sheng Li‡, Amane Mochizuki*‡ and Ghassan E. Jabbour*†§
† School of Materials, Advanced Photovoltaic Center, Arizona State University, Tempe, Arizona, 85287-6006
‡ Nitto Denko Technical Corporation, 501 Via Del Monte, Oceanside, California 92058
Chem. Mater., 2010, 22 (16), pp 4776–4782
DOI: 10.1021/cm101314b
Publication Date (Web): July 21, 2010
Copyright © 2010 American Chemical Society
*Authors to whom correspondence should be addressed. E-mail addresses: [e-mail], [e-mail] (G.E.J.), [e-mail] (A.M.)., §

Current address: Solar and Alternative Energy Engineering Research Center, Physical Science and Engineering, KAUST, Thuwal, Saudi Arabia.
Abstract
Abstract Image

The synthesis, photophysical, and electrochemical characterization of macromolecules, consisting of an emissive platinum complex and carbazole moieties covalently attached to a polyhedral oligomeric silsesquioxane (POSS) core, is reported. Organic light-emitting devices based on these POSS materials exhibit a peak external quantum efficiency of ca. 8%, which is significantly higher than that of the analogous devices with a physical blend of the platinum complexes and a polymer matrix, and they represent noticeable improvement in the device efficiency of solution-processable phosphorescent excimer devices. Furthermore, the ratio of monomer and excimer/aggregate electroluminescent emission intensity, as well as the device efficiency, increases as the platinum complex moiety presence on the POSS macromolecules decreases.

Dissect away Hawk

http://pubs.acs.org/doi/abs/10.1021/ja908139y?prevSearch=%2528%2522michael%2Bs.%2BWong%2522%2529%2BNOT%2B%255Batype%253A%2Bad%255D%2BNOT%2B%255Batype%253A%2Bacs-toc%255D&searchHistoryKey=

think this one had to do with the frog lit up with qd

Article
Self-Assembly Synthesis, Tumor Cell Targeting, and Photothermal Capabilities of Antibody-Coated Indocyanine Green Nanocapsules

* Abstract
* HTMLFull Text HTML
* PDFHi-Res PDF[3635 KB]
* PDFPDF w/ Links[442 KB]

* Supporting Info
* Figures
* Citing Articles

Jie Yu†, David Javier‡, Mohammad A. Yaseen‡§, Nitin Nitin‡, Rebecca Richards-Kortum‡, Bahman Anvari and Michael S. Wong*†
Department of Chemical and Biomolecular Engineering, Department of Bioengineering, and Department of Chemistry, Rice University, Houston, Texas 77251, Department of Radiology, Massachusetts General Hospital, Charlestown, Massachusetts 02129, and Department of Bioengineering, University of California, Riverside, California 99251
J. Am. Chem. Soc., 2010, 132 (6), pp 1929–1938
DOI: 10.1021/ja908139y
Publication Date (Web): January 21, 2010
Copyright © 2010 American Chemical Society
[e-mail], †

Department of Chemical and Biomolecular Engineering, Rice University.
, ‡

Department of Bioengineering, Rice University.
, §

Current address: Massachusetts General Hospital.
,

Department of Bioengineering, University of California, Riverside.
,

Department of Chemistry, Rice University.
Abstract
Abstract Image

New colloidal materials that can generate heat upon irradiation are being explored for photothermal therapy as a minimally invasive approach to cancer treatment. The near-infrared dye indocyanine green (ICG) could serve as a basis for such a material, but its encapsulation and subsequent use are difficult to carry out. We report the three-step room-temperature synthesis of 120-nm capsules loaded with ICG within salt-cross-linked polyallylamine aggregates, and coated with antiepidermal growth factor receptor (anti-EGFR) antibodies for tumor cell targeting capability. We studied the synthesis conditions such as temperature and water dilution to control the capsule size and characterized the size distribution via dynamic light scattering and scanning electron microscopy. We further studied the specificity of tumor cell targeting using three carcinoma cell lines with different levels of EGFR expression and investigated the photothermal effects of ICG containing nanocapsules on EGFR-rich tumor cells. Significant thermal toxicity was observed for encapsulated ICG as compared to free ICG at 808 nm laser irradiation with radiant exposure of 6 W/cm2. These results illustrate the ability to design a colloidal material with cell targeting and heat generating capabilities using noncovalent chemistry