Thursday, October 07, 2010 5:35:45 PM
Either way, you probably can't get the ADME good enough for the idea to work. Hence the delay in human studies.
And then the final blow is the impossibility of halting the virus when one needs to - when it is in the cell. The folks who don't get HIV despite exposure have a cell surface CCR mutation that stops the virus from entering immune system cells. Destroying viruses in the bloodstream is meaningless.
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