Followers | 261 |
Posts | 19732 |
Boards Moderated | 0 |
Alias Born | 10/03/2004 |
Monday, July 19, 2010 4:07:42 PM
By Courtney Humphries -- Monday, July 19, 2010
[When this technology is ready, this skin patch could very well be a method of delivery for HivCide maintenance, once that is also approved as part of the HAART cocktail. --Doc FG]
Getting vaccinated for the flu or other infections could become as easy as pressing a patch onto the skin--no shot in the arm required
No needle: Microneedles made of a polymer that dissolves in body tissues can be used to deliver vaccines directly and painlessly into the skin. The microneedles shown here, inserted into pig skin, dissolve in a matter of minutes.
Credit: Sean Sullivan, Georgia Institute of Technology
A new paper published in Nature Medicine describes a patch that holds an array of microneedles that administer a vaccine and dissolve painlessly. That could make it possible for people to get inoculated more easily and even administer their own vaccines.
Most vaccines are delivered by an injection into muscle. But Mark Prausnitz, lead author of the paper and a chemical and biological engineer at Georgia Institute of Technology, says that the surface of the skin could be a better entry point. Because the body expects to encounter harmful invaders on its surfaces, the skin is loaded with cells that can launch an immune response--a key step for a vaccine to work.
Researchers have investigated other microneedle patches as a way to deliver drugs. This version, a collaboration between the labs of Prausnitz and Richard Compans, a microbiologist at Emory, adds an innovation: The needles are constructed out of a polymer that dissolves in bodily fluids. Just several hundred micrometers in length, the needles can penetrate the outer layers of the skin before melting away in a few minutes. As they do so, a vaccine encapsulated in the needles travels into the skin. Only a thin biodegradable backing is left behind, and it washes away in water.
Researchers tested the patches on mice and found that the animals that received the flu vaccine by skin patch could fight off an infection 30 days later just as well as mice that had received an injection. Furthermore, mice vaccinated through the skin had a much lower level of virus in their lungs, suggesting that the patch could provoke a more effective immune response.
Prausnitz and his collaborators are seeking funding for a clinical trial of the influenza vaccine patch in humans. They are also investigating the possibility of using a similar system for other types of infectious diseases.
http://www.technologyreview.com/biomedicine/25818/
Recent NNVC News
- NanoViricides Reports that the Phase I NV-387 Clinical Trial is Completed Successfully and Data Lock is Expected Soon • InvestorsHub NewsWire • 05/02/2024 02:07:42 PM
- Form 8-K - Current report • Edgar (US Regulatory) • 02/16/2024 09:53:32 PM
- Form 10-Q - Quarterly report [Sections 13 or 15(d)] • Edgar (US Regulatory) • 02/14/2024 09:55:35 PM
- Form 8-K - Current report • Edgar (US Regulatory) • 01/19/2024 09:44:48 PM
- Form DEF 14A - Other definitive proxy statements • Edgar (US Regulatory) • 12/04/2023 09:08:49 PM
- Form 10-K - Annual report [Section 13 and 15(d), not S-K Item 405] • Edgar (US Regulatory) • 10/13/2023 08:30:41 PM
- Form NT 10-K - Notification of inability to timely file Form 10-K 405, 10-K, 10-KSB 405, 10-KSB, 10-KT, or 10-KT405 • Edgar (US Regulatory) • 09/28/2023 08:44:54 PM
- Form 8-K - Current report • Edgar (US Regulatory) • 09/01/2023 08:46:45 PM
Cannabix Technologies and Omega Laboratories Inc. Provide Positive Developments on Marijuana Breathalyzer Testing • BLO • Jul 11, 2024 8:21 AM
ECGI Holdings Enhances Board with Artificial Intelligence (AI) Expert Ahead of Allon Apparel Launch • ECGI • Jul 10, 2024 8:30 AM
Avant Technologies to Meet Unmet Needs in AI Industry While Addressing Sustainability Concerns • AVAI • Jul 10, 2024 8:00 AM
Panther Minerals Inc. Launches Investor Connect AI Chatbot for Enhanced Investor Engagement and Lead Generation • PURR • Jul 9, 2024 9:00 AM
Glidelogic Corp. Becomes TikTok Shop Partner, Opening a New Chapter in E-commerce Services • GDLG • Jul 5, 2024 7:09 AM
Freedom Holdings Corporate Update; Announces Management Has Signed Letter of Intent • FHLD • Jul 3, 2024 9:00 AM