Two things: First those are great questions for the company.
Second, some people with Engineering degrees spent three days trying to explain the baseline to me. It has to do with mathematical algorithms which look at variations between what's called the reference frequency, the delta frequency and the measured frequency....
Here's some of the raw info from the patents which discuss this.
The system according to claim 1, wherein the analog circuit 2 comprises: a multi-channel multiplexer 22 for selecting a channel from the sensor probe 1; a sensor selection unit 23 for selecting specific sensors among multi-channel sensors from the sensor probe 1 and selecting a sensor for measurement from the specific sensors; a frequency controller 24 for minimizing errors such as an error caused when a region of the biosensors of the sensor probe 1 is composed of multiple channels, a basic manufacturing error of electronic components, and an environmental error of a measurement region and the like and adjusting a frequency generated in a frequency oscillation circuit 20 to a reference frequency of the sensor accurately; a frequency generator 25 for generating a reference frequency unique to the sensors based on the capacitance element when the biosensors in the sensor probe 1 is in a normal state before their diagnosis; a frequency signal amplifier 26 for amplifying level of a frequency signal generated from the frequency generator 25 up to a level where the frequency signal can be in the digital conversion circuit 3; and a frequency allocator 27 for allocating the frequency to be measured in the digital conversion circuit 3.
. The system according to claim 1, wherein the health condition of the subject is determined according to a variation of a delta frequency which is a difference value between the reference frequency unique to the biosensor and the measured frequency detected by the biosensor.
10. The system according to claim 9, wherein the difference value between the reference frequency and the measured frequency is determined by determining a delta frequency using a clock of the CPU 11 supplied through an oscillator 10 and a voltage-frequency (VF) converter, measuring the frequency oscillated from the sensor, and comparing the measured frequency with the reference frequency.
11. The system according to claim 9, wherein the difference value between the reference frequency and the measured frequency is determined by converting a voltage value into a digital value and comparing the measured frequency with the reference frequency, the voltage value being obtained by passing the frequency outputted from the sensor through a frequency-voltage (FV) converter using an A/D converter inside or outside of the CPU 11 in measuring the frequency oscillated from the sensor.
12. The system according to claim 9, wherein the reference frequency is a reference frequency for comparing with the measured frequency detected by the biosensor when the biosensor is free from the exposure to the bio-action potential, and which is adjusted to the same frequency as the frequency unique to the biosensor
The system according to claim 12, wherein the reference frequency of the sensor as the frequency unique to the biosensor has a frequency band range from 0.5 Hz to 95 MHz.
14. The system according to claim 13, wherein the reference frequency is primarily calibrated in the analog circuit and secondarily adjusted to the same frequency as the frequency unique to the biosensor by the digital conversion circuit and a given program, in consideration of the characteristics of the biosensor sensitive to measurement environments.
15. The system according to claim 14, wherein the reference frequency that can be adjusted by an analog mode is in a range from 5 Khz to 10 Mhz.
16. The system according to claim 14, wherein the reference frequency that can be adjusted by a digital mode is in a range from 0.1 hz to 1 Mhz.
[0114]In the disease diagnostic system according to the present invention, the value of the basic capacitance of the biosensor is varied slightly during the process for manufacturing the sensor probe 1. Accordingly, although the value of the reference frequency is adjusted in the analog circuit 2 as shown in FIG. 8, the value of the basic frequency may be varied slightly due to the change in the capacitance value.
[0115]Therefore, a process of reference frequency control is carried out according to an algorithm shown in FIG. 11. That is, channels are selected by the channel frequency selection unit 18, the reference frequency of a material for the detection of biological electromagnetic signals (biosensor) for each channel is set by using the frequency control oscillator 16a, and then the CPU 11 stores sequentially voltage value of each channel to each channel in memory areas of the SDRAM 13.
The standard of the difference value of the frequency classifying "green", "yellow" and "red" is set on the basis of the results obtained by carrying out pre-animal clinic tests several hundreds times, which was conducted in "UNI Bio-Tec" company. As an experimental example, assume that the reference frequency is 50.40 KHz. At this time, a mouse is very good in health so "green" is indicated if the measured frequency is within the range from 50.40 to 48.38 KHz, the mouse is good in health so "yellow" is indicated if the measured frequency is within the range from 48.37 to 46.79 KHz, and the mouse is inflammatory so "red" is indicated if the measured frequency is less than 46.78 KHz. If "yellow" and "red" are irregularly indicated, it is judged to be cancer.
[0155]Upon being transmitted to the PC from the diagnostic device equipped with the material for the detection of biological electromagnetic signals (biosensor) as above, the transmitted data is transmitted according to a specific data transmission protocol by the wireless communication module 19a, the USB port 19b and the RS-232C 19c of the PC or diagnostic device.
[0156]In addition, an audio signal is outputted through the buzzer 16b so that the biological electromagnetic signal inputted from the material (biosensor) can be heard. As different sounds are generated according to colors displayed on the LCD 15, normal condition, inflammation and cancer can be judged by sounds.
When the diagnostic device is powered on and actuated, a reference frequency is established. As a diagnosis begins, a frequency a measured according to the health condition of a subject, and a difference between the reference frequency and the measured frequency is calculated as a delta frequency. The health condition of the subject can be judged based on the magnitude of the measured frequency or delta frequency. Furthermore, since the magnitude of the measured frequency or delta frequency is a value proportional to a change in the capacitance of the material of the invention, the health condition of the subject can be judged based on the change in the capacitance of the material.
According to measurement results, at a reference frequency of 50,400 Hz of the diagnostic device manufactured in Example 16, those mice showing a measurement frequency of 50,400 Hz to 48,380 Hz were very healthy (green), and those mice showing a measurement frequency ranging from 48,370 Hz to 46,790 Hz were relatively healthy (yellow). When "yellow" and "red" were displayed irregularly, it is judged to be cancer. In the respective judgment, reference points were established by results obtained by experiences of the inventors and preliminary experiments, and previously inputted so that the CPU of the diagnostic device can make judgment according to frequency values of corresponding ranges. In particular, the differences of measurement frequencies in respective measurements are maintained uniform in the case of normal condition. In the case of inflammation, the measurement frequencies are lower than those of the normal condition but maintain uniform frequency differences. However, in the case of cancer, the measurement frequencies showed a large deviation, in particular, maintained a similar or lower level than the case of inflammation, suddenly rose to the level of normal frequency range, and then dropped to the frequency range of inflammation. In this way, the measurement frequencies show large differences at respective measurements.
According to measurement results, at a reference frequency of 50,400 Hz of the diagnostic device manufactured in Example 16, those mice showing a measurement frequency of 50,400 Hz to 48,380 Hz were very healthy (green), and those mice showing a measurement frequency ranging from 48,370 Hz to 46,790 Hz were relatively healthy (yellow). When "yellow" and "red" were displayed irregularly, it is judged to be cancer. In the respective judgment, reference points were established by results obtained by experiences of the inventors and preliminary experiments, and previously inputted so that the CPU of the diagnostic device can make judgment according to frequency values of corresponding ranges. In particular, the differences of measurement frequencies in respective measurements are maintained uniform in the case of normal condition. In the case of inflammation, the measurement frequencies are lower than those of the normal condition but maintain uniform frequency differences. However, in the case of cancer, the measurement frequencies showed a large deviation, in particular, maintained a similar or lower level than the case of inflammation, suddenly rose to the level of normal frequency range, and then dropped to the frequency range of inflammation. In this way, the measurement frequencies show large differences at respective measurements
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