Wednesday, August 05, 2009 6:35:09 PM
TapImmune’s vaccine technology is based on modulating the activity of the antigen processing machinery (APM) to increase effective presentation of antigens to the immune system. Transporters associated with antigen processing (TAP) play a major role in the antigen processing pathway by supplying suitable antigenic peptides to the MHC class I complex. Nearly all cell types display MHC class I antigen on their surface and provide the information to the immune system. The immune system uses this information to selectively destroy cancerous cells or those infected with pathogens. When a virus infects a cell, the viral protein components are degraded by the proteasome into smaller peptide components; TAP then facilitates the binding of the foreign peptides of viral origin to the MHC class I complex and these are subsequently display on the infected cell’s surface. Cytotoxic T-Cells recognize foreign peptides bound to the MHC class I antigen on the cell surface and destroy infected cells to prevent the spread of this infection
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