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Post# of 4974714
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Monday, 04/27/2009 11:20:11 AM

Monday, April 27, 2009 11:20:11 AM

Post# of 4974714
HEB exploding on news of the swine Flu

Not only that, but it has an FDA approval coming next month.

BOSTON (MarketWatch) -- Shares of niche makers of antiviral products and vaccines saw shares rocket in early trading Monday on news that the world could be facing a global pandemic of the swine flu virus.

Concerns about the growing health crisis helped boost drug stocks into positive territory while the broader market slid into the red. The Amex Pharmaceutical Index (DRG ) rose 1.2% to 236.04 and the Amex Biotechnology Index (BTK ) jumped 1.5% to 626.90. Meanwhile, the Dow Jones Industrial Average slid about 65 points, or 0.8%, to 8,009.

Leading the pack was Biota Holdings Ltd. (BTAHY, Trade )(BTAHF, Trade ), with U.S.-traded shares shooting up over 600% to $4.40. Australia-based Biota receives royalties on a leading flu-fighting agent, Relenza, which is marketed by GlaxoSmithKline PLC. (GSK, Trade )

Also gaining at least 50% were Generex Biotechnology Corp. (GNBT, Trade ), BioCryst Pharmaceuticals (BCRX, Trade ), Novavax Inc. (NVAX, Trade ) and Hemispherx Biopharma Inc (HEB, Trade ). Advancing at least 15% were shares of Vical Inc. (VICL, Trade ) and Peregrine Pharmaceuticals. (PPHM, Trade )

Many of the companies have also been active in developing products to combat a deadly strain of the avian flu called H5N1, which has been eyed over the years by world health officials as a pandemic threat. The current swine flu virus is of a strain called H1N1.

Large-scale anti-viral developers Gilead Sciences (GILD, Trade ), Roche Holding (RHHBY, Trade ) and GlaxoSmithKline PLC were also up significantly.

Gilead developed a leading flu-fighter, Tamiflu, also called oseltamivir. The biotech group receives royalties on Tamiflu sales from marketer Roche (RHHBY, Trade ).

Shares of Gilead were up 3% at $47.03, as shares of Roche climbed 4% to $31.54. Shares of Glaxo were up 6% at $31.03.

Gilead reported last week that it took in $33 million in Tamiflu royalties, down from $93 million the previous year. Gilead attributed the drop to stockpiling by health agencies worldwide in preparation of a possible pandemic of the avian flu virus.

According to Biota's website, Relenza had sales of $462 million for the quarter ended March 31, garnering the company about $32 million in royalties. Biota noted that the U.K. and British governments had recently ordered "significant" amounts of the product as part of their pandemic stockpiling measures.

Lazard Capital Markets analyst Joel Sendek said in a note early Monday that the Centers for Disease Control suspects other flu-fighting agents are ineffective against the swine flu virus and is recommending either oseltamivir or zanamivir to treat patients.

"Gilead is likely a beneficiary of the current situation. We anticipate increased retail sales of Tamiflu as people with suspicious symptoms consistent with the flu are likely to purchase Tamiflu. We also expect additional government stockpiling in the future given the scale and speed of the current swine flu emergency," wrote Sendek, who tracks Gilead.

Trading amongst the remaining major vaccine makers was more mixed. As opposed to other pharmaceutical products, flu vaccines require months of production.

Shares of Baxter International (BAX, Trade ) rose 3% to $49.33, while AstraZeneca PLC (AZN, Trade ) shares were up 5% at $36.36. Shares of Sanofi-Aventis (SNY, Trade ) edged up 2% to $27.27.

Novartis AG (NVS, Trade ) was the only large-scale vaccine maker trading in the red, with shares down almost 1% at $36.66.
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