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Re: worktoplay post# 12856

Wednesday, 03/03/2004 10:27:45 AM

Wednesday, March 03, 2004 10:27:45 AM

Post# of 82595
Another excerpt:

The primary element of the disclosed methods is that most human traits can be predicted through a detailed measurement of AIMs associated with population structure at various levels, provided the trait correlates with that element of structure. A secondary element is that classifiers, or collections of SNP markers, and methods for predicting trait value from DNA can be constructed for most human traits through such an appreciation of population structure. As disclosed herein, such applications can be accomplished through correlation, not just through extended LD found in certain admixed groups such as Hispanics or African Americans, but for any sample of subjects, regardless of race or ethnic background, provided that the AIMs used are appropriate for the element of population structure with which the trait is correlated. These results can be attained because the methods of the invention provide a means to mine the genome for good AIMs, qualify their value as AIMs and accurately measure population structure against the backdrop of human phenotypes.

The use of population structure to infer the trait is the phenomenon DNAPrint has referred to and can be used to infer ANY trait. According to my previous post, they have already catalogued 54 drug response traits for 23 different drugs.

Later,
W2P