Wednesday, March 03, 2004 10:19:05 AM
When combined with markers from genes that are biologically relevant for response, they augment the ability to make accurate inferences of response from the DNA. Each of these markers also is an excellent AIM, indicating that the linkage of the AIMs to drug response is likely a function of ancestral differences in response proclivity (see Example [5).] As such, ancestral heritage can be predictive of favorable response to [LIPITOR.] This association has been observed for almost every type of response (n = 54) to almost every type of drug (n = 23) examined, thus confirming that the inference of drug response can be accomplished, at least in part, through the inference of ancestral proportions. As such, it appears that the genes truly relevant for drug response are a function, at least in part, of individual ancestry, and that the gene sequences relevant for drug response are statistically linked with markers that are informative as to ancestry (i. e., [AIMS).]
DNAP has catalogued 54 different response types to 23 different drugs and linked them genetically to Ancestry.
Later,
W2P
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