Repros Therapeutics, Inc. (RPRX)

[rfj1862]

You have cause and effect backwards. The reason women aren't on Lupron long-term is because of all of the bad effects of suppressing estrogen.

In terms of long-term clinical benefit, you have to juxtapose these results against Lupron. Nobody is suggesting that Proellex is going to be marketed for osteoporosis. Instead, the absence of effect on markers of bone turnover makes Proellex a viable long-term treatment for endometriosis and UF, which Lupron can't be for the very reason that it suppresses estrogen, eliciting osteoporosis etc.