RespireRx Pharmaceuticals Inc (RSPI)

[K-G]

Semi-OT - Some casual observations on Paxil.
The successful uses of Paxil that I have observed have been related to anxiety disorders. In these cases, Paxil has had a dramatic impact. All (n~5) have observed significant mental effects with slight changes in dosage, and the best approach seems to be start at a low dosage (< 5 mg), build slowly up to a sustaining level, then very slowly taper down to find a minimum effective dosage for the individual. My wife is one of these patients, and her current dose at 1 to 2 mg once daily is well below most starting dosages, but still has a very noticeable positive effect at managing her anxiety level. Other patients (including my wife) that have started at higher dosages (10 – 20 mg BID), or who have changed dosage (higher and lower) by similar amounts have experienced mental and physical impairment (disorientation, hallucinations, ‘fogginess’, fatigue). These same folks have benefitted from the higher or lower dosages if they are slowly reached.