Mohacsy's Safe Portfolio Member Forum : Hundreds of thousands of workers are bei...

Hundreds of thousands of workers are being furloughed,

santafe2 · 2025-04-04T16:40:45.2030000Z

Hundreds of thousands of workers are being furloughed, laid off or fired in the private sector as well as the 300,000 expected to be fired in the federal work force. Trump is actively forcing Powell's hand. Abe Lincoln almost 200 years ago: At what point then is the approach of danger to be expected? I answer, if it ever reach us, it must spring up amongst us. It cannot come from abroad. If destruction be our lot, we must ourselves be its author and finisher. As a nation of freemen, we must live through all time, or die by suicide.

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Proactive - Interviews for investors

OKYO Pharma achieves key stability milestone for Urcosimod in clinical development

OKYO Pharma CEO Gary Jacob joined Steve Darling from Proactive to share a significant advancement in the company’s ongoing drug development efforts. The company has successfully demonstrated that urcosimod—formerly known as OK-101—remains stable for more than two and a half years in single-use ampoules, which are used for patient administration. This milestone is a crucial step forward in ensuring the long-term viability of the drug as it progresses through clinical trials. Urcosimod is currently being evaluated in a Phase 2b clinical trial, which is a randomized, placebo-controlled, double-masked study involving 48 patients. The trial is focused on assessing the drug’s effectiveness in treating neurotrophic keratopathy (NCP), a serious and progressive degenerative eye disease. Jacob emphasized that achieving success in clinical development extends beyond obtaining positive clinical trial data. A crucial aspect of regulatory approval includes meeting the rigorous Chemistry, Manufacturing, and Controls (CMC) requirements set by the U.S. Food and Drug Administration (FDA). By demonstrating long-term stability, OKYO Pharma has strengthened its regulatory submission package, addressing an essential factor in the drug’s future approval and commercialization. The company recently completed Good Manufacturing Practice (GMP) stability assay testing of single-use ampoules containing urcosimod in an ophthalmic solution. The results were highly promising—ampoules stored under refrigerated conditions maintained stability for over two and a half years, while initial three-month data from samples stored at room temperature showed potency levels at or above 100%. These findings reinforce confidence in urcosimod’s shelf life and its potential for real-world clinical use. As OKYO Pharma continues to advance urcosimod through the regulatory and clinical development process, this stability milestone represents a critical achievement in its journey toward providing an effective tr

Proactive - Interviews for investors

Directa Plus CEO on Q1 revenue jump on new contracts in Romania and textile market recovery

Directa Plus CEO Giulio Cesareo talked with Proactive's Stephen Gunnion about the company’s strong start to 2025 and the strategic impact of its environmental operations. Cesareo shared that the company saw a 40% rise in first-quarter revenue to approximately €2 million, driven by new contracts in Romania and a recovering textile market in Italy. “We have a significant contract with Midia International,” Cesareo explained, adding that work on oil recovery from drilling platforms resumed after a slowdown in 2024 due to the war in the Black Sea. The full acquisition of Setcar, a Romanian environmental service company, plays a central role in the company’s strategy. Cesareo highlighted that Setcar not only holds a full suite of environmental certifications but also occupies a “geopolitical significant position” as a potential gateway to Ukraine’s reconstruction. Environmental applications remain a key focus for Directa Plus, especially the use of its graphene materials to decontaminate water and soil. In collaboration with OMV Petrom, the company successfully decontaminated 44,000 cubic meters of water, recovering 10,000 barrels of crude oil. Research and development are also advancing. Directa Plus is working with Nant G Power on battery materials and refocusing on opportunities in sectors like tyres and PFAS filtration. Cesareo stated, “There are significant opportunities, despite the actual crisis, that can be captured by our innovative material.” With €4 million in cash and a burn rate that extends funding through to August 2026, Cesareo believes the company is well-positioned for the year ahead. For more exclusive interviews and updates, visit Proactive's YouTube channel. Don’t forget to like this video, subscribe, and enable notifications to stay up to date. #DirectaPlus #GrapheneTechnology #EnvironmentalSolutions #Setcar #OilRecovery #PFAS #CleanTech #NantGPower #UkraineReconstruction #TextileInnovation #BatteryMaterials #Q12025 #InvestingInGraphene #Proa

Proactive - Interviews for investors

Nexus Minerals expands Payns Find gold target

Nexus Minerals Ltd managing director Andy Tudor talked with Proactive about the latest exploration success at the Payns Find gold target, part of the company's Wallbrook Gold Project in Western Australia. Tudor described the program as “exciting” following a third air core drilling campaign that confirmed high-grade intercepts and significantly expanded the mineralised footprint. He said, “All of the attributes for a big system are here,” highlighting consistent grades of up to 5.99g/t at the extremities of a 900m by 750m target zone. The air core results revealed both supergene and fresh rock mineralisation, with around 30% of the 163 holes showing elevated geochemistry in the final metre — a strong indicator of a large underlying system. “It’s that grade in the supergene and in the fresh rock that’s got us excited,” Tudor said. He also pointed to the presence of a full suite of alteration minerals — cerussite, rutile, tourmaline, and albite — typically associated with major gold systems in the region. With the air core phase now complete, Nexus is turning to reverse circulation (RC) drill planning. Tudor confirmed that air core drilling would continue regionally, while the company prepares for a comprehensive RC program at Payns Find to test depth extensions down to 120–150m. Visit Proactive's YouTube channel for more company interviews, and don’t forget to like this video, subscribe to the channel, and hit the notification bell for future updates. #NexusMinerals #GoldExploration #ASXStocks #WallbrookProject #PaynsFind #GoldMiningWA #RCDrilling #JuniorMiners #ASXNXM #MiningNews

Proactive - Interviews for investors

Zinnwald Lithium wins Saxony government endorsement for lithium project after robust PFS

Zinnwald Lithium PLC (LSE:ZNWD, OTC:ZNWLF) chief executive Anton du Plessis talked with Proactive's Stephen Gunnion about the company’s recently published pre-feasibility study (PFS) for its Zinnwald Lithium Project, located in Saxony, Germany. The project is designed to supply battery-grade lithium hydroxide to the European market and has now received public backing from the Saxony government. Du Plessis outlined that the PFS demonstrates a scalable, long-life mining operation, starting with 18,000 tonnes per annum of lithium hydroxide and potentially scaling to 35,000 tonnes in a second phase. He stated, “We published our PFS on Monday that showed an economic project of significant scale… a globally significant project in terms of scale.” The economics were highlighted as robust, with a post-tax NPV of €2.20 billion and an internal rate of return of approximately 20%. The location of the project — 35km south of Dresden — positions it strategically at the heart of Germany and the EU, aligning with Europe’s push for regional supply chains of critical raw materials. Du Plessis also emphasised the importance of the local endorsement, noting, “To have the public endorsement, as we had, is extremely important to us.” The next step for the company is to optimise the project in preparation for a Definitive Feasibility Study, expected in 2026. Visit Proactive's YouTube channel for more interviews like this. Don't forget to like this video, subscribe to the channel, and hit the notification bell to stay updated on future content. #Lithium #BatteryMetals #ZinnwaldLithium #GermanMining #Saxony #CriticalMinerals #EVsupplychain #LithiumHydroxide #EUrawmaterials #MiningInvestment #PFS #CleanEnergy #ZinnwaldProject

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